# Valium

In the chapter about long-term trends I made the point that smoking has been declining since the 1960’s in the USA (and that bans really has had no effects on this trend). I speculated that this could be due to an increase in healthy life-styles in the USA (gym, natural foods, etc.).

However, there is a much more likely explanation: Valium and Prozac. I have yet to read anybody from the anti-smoking league raising this as a likely reason, nor have I heard the pharmacological companies claiming this as a benefit for their drug!

Play this song while you are reading the rest of this page:

Here are some extracts from wikipedia about diazepam – the pharmacological name for Valium.

Diazepam (play/dˈæzɨpæm/), first marketed as Valium (play/ˈvæliəm/) by Hoffmann-La Roche, is a benzodiazepinedrug. Diazepam is also marketed in Australia as Antenex. It is commonly used for treating anxietyinsomniaseizures including status epilepticusmuscle spasms (such as in cases oftetanus), restless legs syndromealcohol withdrawalbenzodiazepine withdrawal and Ménière’s disease. It may also be used before certain medical procedures (such as endoscopies) to reduce tension and anxiety, and in some surgical procedures to induce amnesia.[1][2] It possesses anxiolytic,anticonvulsanthypnoticsedativeskeletal muscle relaxant, and amnestic properties.[3] The pharmacological action of diazepam enhances the effect of the neurotransmitter GABA by binding to the benzodiazepine site on the GABAA receptor (via the constituent chlorine atom) leading to central nervous systemdepression.[4]

History

Diazepam was the second benzodiazepine to be invented by Dr. Leo Sternbach of Hoffmann-La Roche, following chlordiazepoxide (Librium) which was approved for use in 1960. Released in 1963 as an improved version of Librium, diazepam became incredibly popular, helping Roche to become a pharmaceutical industry giant. It is two and a half times more potent than its predecessor, which it quickly surpassed in terms of sales. After this initial success, other pharmaceutical companies began to introduce other benzodiazepine derivatives.[98]

The benzodiazepines gained popularity among medical professionals as an improvement upon barbiturates, which have a comparatively narrow therapeutic index, and are far more sedating at therapeutic doses. The benzodiazepines are also far less dangerous; death rarely results from diazepam overdose, except in cases where it is consumed with large amounts of other depressants (such as alcohol or other sedatives).[63] Benzodiazepine drugs such as diazepam initially had widespread public support, but with time the view changed to one of growing criticism and calls for restrictions on their prescription.[99]

Diazepam was the top-selling pharmaceutical in the United States from 1969 to 1982, with peak sales in 1978 of 2.3 billion tablets.[98] Diazepam, along with oxazepamnitrazepam and temazepam, represents 82% of the benzodiazepine market in Australia.[100] While psychiatrists continue to prescribe diazepam for the short-term relief of anxiety, neurology has taken the lead in prescribing diazepam for the palliative treatment of certain types of epilepsy and spastic activity, for example, forms of paresis. It is also the first line of defense for a rare disorder called stiff-person syndrome.[27] In recent years, the public perception of benzodiazepines has become increasingly negative.[83]

Recreational use

Diazepam is a drug of potential abuse and can cause serious problems of addiction and as a result is scheduled. Urgent action by national governments has been recommended to improve prescribing patterns of benzodiazepines such as diazepam.[5][83] A single dose of diazepam modulates the dopamine system in similar ways to how morphine and alcohol modulate the dopaminergic pathways.[101] Between 50 and 64% of rats will self administer diazepam.[102] Benzodiazepines including diazepam in animal studies have been shown to increase reward seeking behaviours by increasing impulsivity, which may suggest an increased risk of addictive behavioural patterns with usage of diazepam or other benzodiazepines.[103] In addition diazepam has been shown to be able to substitute for the behavioural effects of barbiturates in a primate study.[104] Diazepam has been found as an adulterant in heroin.[105]

Diazepam drug misuse can occur either through recreational misuse where the drug is taken to achieve a high or when the drug is continued long term against medical advice.[106]

Sometimes Diazepam is used by stimulant users to “come down” and sleep and to help control the urge to binge.[107]

A large-scale nationwide USA government study conducted by SAMHSA found that benzodiazepines in the USA are the most frequently abused pharmaceutical with 35% of drug-related visits to the Emergency Department involved benzodiazepines. Benzodiazepines are more commonly abused than opiate pharmaceuticals, which accounted for 32% of visits to the emergency department. No other pharmaceutical is more commonly abused than benzodiazepines. Males abuse benzodiazepines as commonly as females. Of drugs used in attempted suicide benzodiazepines are the most commonly used pharmaceutical drug, with 26% of attempted suicides involving benzodiazepines. The most commonly abused benzodiazepine is, however, alprazolamClonazepam is the second-most-abused benzodiazepine. Lorazepam is the third-most-abused benzodiazepine, and diazepam the fourth-most-abused benzodiazepine in the USA.[108]

Benzodiazepines, including Diazepam, nitrazepam, and flunitrazepam account for the largest volume of forged drug prescriptions in Sweden, a total of 52% of drug forgeries being for benzodiazepines.[109]

Diazepam was detected in 26% of cases of people suspected of driving under the influence of drugs in Sweden and its active metabolite nordazepam was detected in 28% of cases. Other benzodiazepines and zolpidem and zopiclone also were found in high numbers. Many drivers had blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.[110] In Northern Ireland in cases where drugs were detected in samples from impaired drivers who were not impaired by alcohol, benzodiazepines were found to be present in 87% of cases. Diazepam was the most commonly detected benzodiazepine.[111]

I think the important point raised above is that Valium affects the Dopamine pathways, which is also what nicotine does.

 

 

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